When using Radeon Relive to record or stream, if you change focus such as alt-tabbing while recording, or in my case shortly after ending a record (while the overlay stating the video was saved in the chosen directory) it may cause a Driver crash or system lockup, or both. I believe it is caused by the overlays that popup when you use a radeon relive hotkey.
One request I have to AMD is the ability to turn those overlay items off completely until the issue with them is fixed. In my experience, also with Radeon VII, they either flicker weirdly or now cause the driver to crash.