Have you tried updating the Mouse driver?
Edit: Their is a current AMD Forum Thread open about this exact problem. amdmatt asking for DiagDX to be sent to him for Engineering. Here is the thread that you can also post your problem on: AMD Radeon Software 18.5.1 freezes my computer every 5 seconds
Please supply the following computer information as required by AMD Forums rules: INFORMATION REQUIRED WHEN POSTING A QUESTION
AMD and Windows 10 April update issue.
See also: AMD Radeon Software 18.5.1 freezes my computer every 5 seconds
Would like to get this fixed.