Radeon Image Sharpening not available with Mass Effect Andromeda
The issue has been going on for some time now.
In Andromeda's gaming profile, the option RIS is unavailable and can't be modified. When launching the game, Radeon Software keeps mentioning that Andromeda is compatible with CAS, which is not true. The game has no built-in option for Contrast Adaptive Sharpening.
Please fix your game database and unlock RIS for Andromeda in Radeon Software options.