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1. Radeon 2400 will work and is officially support. Radeon 3650 is not officially supported but "unofficially" should work.
Note that neither 2400 nor 3650 have double precision or global buffer.
2. I believe there will be some penalty as threads are organized into "wavefronts" and different control paths should get serialized. This is similar to CUDA.
3. No idea.
4. Multi-gpu seems to be supported. Crossfire needs to be disabled. Each gpu should be attached to a display I believe.
Vista support is coming. That should include 32 and 64.
VS2008 support was added in v1.1-beta. Give it a try and let us know if you find problems with it.
For multi-GPU support in Brook+, you need to create a separate process to talk to each GPU and set BRT_ADAPTER in the environment appropriate to point to which GPU you want to talk to.