Was thinking of using a Pro Duo and dusting off my Skills in Lightwave3D and Rhino3D. You folks see any issues related to no software specific support
According to LightWave 3D Support if your version, which you didn't indicate, is older than 2015 it isn't compatible with Windows 10 OS and you must upgrade to the latest version: LightWave - Support
The LightWave support web page does not say that older versions are incompatible with Windows 10. It just states that the older versions are unsupported. However, I can affirm that versions of LightWave going back to 4 still work in Windows 10.
LightWave employs a CPU renderer so the graphics card is only used for OpenGL previews. There's very little concern for which graphics card you use.
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