Radeon Software 20.7.2 (latest version as of posting)
Just as it says in the title. When I'm in-game, my manual tuning settings for the game is ignored and the global tuning settings are in use. I keep my global tuning to a very aggressive undervolt (lower frequency) while my some of my game profiles have a more conservative undervolt (higher frequency). It's obvious when I set my global max frequency/voltage compared to the game's tuning; when GPU utilization is near 100%, GPU frequency never goes above the global profile's max frequency.