I recently got the XFX Radeon RX 580, and after installing it there were a lot of problems. Whenever I booted my PC, I would get a black screen with my cursor on it, or I would reach the desktop but everything would be unresponsive. After a little bit of troubleshooting, I discovered that if I unplug the HDMI cable from my VR headset, the problem is fixed. I am using a Displayport going to my monitior, and if I use HDMI instead, nothing changes. It is only when I have an output leading to anything other than my main monitor that the screen bugs out.