I have a mixture of these two gpus in my case, they are working fine I have not encountered really any issues. I use blender and 3ds max and I have been told by a few people that having these mixed gpus you will not have access the the full features and abilities of the Pro or the RX because they are not the same. is this true, I dont know enough about this. I see both in the amd control panel and have access the the Pro setting. I am limiting my speed because I dont have the same cards.