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Can I install 2nd GPU in non-crossfire mode?

Question asked by barabajagal on Jan 21, 2020
Latest reply on Jan 21, 2020 by hardcoregames™

I have read complaints that newer RX 5700 gpu doesn't play well with older games.  I may be experiencing this with my RX 5700 and Rocksmith 2014 Remastered.  My issue is periodic yet random "blank or black" screens during gameplay.  My motherboard is a Gigabyte AB-350 Gaming 3 ( that features two pci slots so it will support two video cards.  My OS is Win 10 build 1903.  I still own an RX 580 (replaced by the RX 5700).  Can I reinstall the RX 580 in the second pci slot and allow the two video cards to operate independently of one another?   Then can I assign older games like Rocksmith to play under the RX 580 and newer titles like Red Dead Redemption 2 to play under the RX 5700?