Hello, it's my first post in the AMD Forums, hope i am doing this right.
I've been having issues with Destiny 2 not showing the FPS counter in the overlay or the game advisor as if the game was not running (not detected by AMD software). I think this was also the cause for big frame drops even on low settings. I tried all sorts of things but what really seems to have fixed it is disabling fullscreen optimizations by right-clicking on the ".exe" > properties > compatibility tab.
I hope it helps other people having this problem or maybe AMD can look into this.
GPU: Sapphire Radeon RX580 8GB Pulse
RAM: 2x8GB HyperX 2400MHz
MB: MSI B360M PRO-VDH
OS: Win10 v1809 (17763.379)