This doesn't always happen, but sometimes when I boot up, the CPU OC settings I had set will be back to stock. Yes, I have the "apply my last settings when system boots" box checked.
FX-8350 @ 4.5GHz
16GB DDR3 1600MHz
750W Rosewill H.I.V.E. PSU
If you are talking about profile settings that are not being applied, enable 'Histograph' in Wattman.