After upgrading from the 18.9.1 to 18.10.1 after opening the Radeon settings by right clicking on the desktop if I click on 'Gaming' the Radeon settings will close. Clicking on any of the other tabs works fine.
Did an uninstall of the drivers then restarted and ran CCleaner reg cleaner. Once complete restarted computer again.
Re-ran the installer for 18.10.1. Once completed rebooted and no more issue.