I have a Radeon R9 200 and have had no trouble with it for quite some time.
About a year or so ago, Windows 10 introduced an update that caused this inverted color flicker to happen any time I alt-tabbed in and out of any game. It wasn't really so much a problem as really annoying.
The solution at the time was to disable "Full screen optimization" as an option for each game executable. This was fine for a while.
With the introduction of DX12, the problem has returned and the same solutions don't fix the problem anymore. If I go back to DX11 the problem goes away, so it's definitely something about DX12, but I don't know if that's necessarily a "Microsoft" problem or not.
What I am not sure of is whether or not this is an AMD-specific problem with DX12 or not, but any help to try and troubleshoot this would be appreciated.