Need to post more information on your computer setup: INFORMATION REQUIRED WHEN POSTING A QUESTION
I don't know if this current thread is applicable to you since you are using a Professional GPU card on your Desktop/Laptop but you may take a look at it: AMD Radeon Software 18.5.1 freezes my computer every 5 seconds .
What type of MiniDP-HDMI adapter to you have installed? is it "Active" or "Passive". "Active" Adapters are more compatible than "Passive" type adapters.