Currently running Windows 18.03 on a Threadripper 1920X based platform.
The combination of IBS with "kernel and user mode" stack samplingin any GUI application reliably results in a bluescreen after a few seconds for me:
DRIVER IRQL NOT LESS OR EQUAL in AMDCpuProfiler.sys
(This problem isn't actually unique to uProf. Older versions of VTune had the very same problem, that performance counters would trigger stack traces at illegal times, resulting in the very same bluescreen.)