I haven't been able to set game profiles in months. The profile settings will not override the Global settings. And...I use Win7.
Try entering the settings you want for the game in the Global setting..and it will apply them in the game...also applies it to every game or application, so it is not a 'fix'..it is proof that they are not working.
Enable the FRTC (frame rate target control) in the game profile..set to 60fps...and play the game. No change in FPS. Now enable FRTC in Global settings and play that game...constant 60fps. As it should.
No Wattman fan or temperature target work in profiles. All use the values in Global settings.