I to have the same issue.
I have tried reinstalling drivers with a clean install, older drivers clean, tried ddu with both older and newer drivers and nothing works.
Everything broke when i upgraded to the newest driver last night.
If it hadent completely trashed my setup i wouldnt be doing this. Also i tried to recal system restore but still same issue.
I have a r9 290x and 3 1080 displays and a fourth that have 4:3 aspect.
I now have no eyefinity and no way of fixing it.
Oh i also tried pulling the fourth screen and do the quicksetup and that worked, untill i put the fourth screen back and rebooted windows. After that the screen resolutions went complete bonkers in a way i cant even describe.
Like i said, r9 290x and tried the maby 5 or 6 latest drivers 18.2.1 being the oldest.
Windows 10 latest update
Installed 17.12.2 and this one workes. Do i realy have to use this old of a driver?
Tried to update the driver again and now i get error 1603. AMD settings fails to install.