What particular settings would those be ?
click on the radeon settings game's Anti-Aliasing Mode and change to override application settings then set to 8x.
Of course you have to try this is game with high demands like crysis 3 .
Or disable vsync in game and set vsync always on in radeon settings profile.
By exemple, to reduce coil whine, i would like to active 'Cibled control frequency' to 60FPS or change v-sync to 'Améliored sync' but nothing happens...