Click the action you want to unbind, and when it asks you to enter a hotkey or press ESC to cancel, just press the Backspace key to unbind
It is not implemented in Radeon Settings UI so you might be disable hotkey with edit Registry.
default settings are:
and user settings (override default settings) are:
Key type is REG_SZ, and you will modify key data to null to erase hotkey.
Keys to config hotkey I found:
Note: Please change registry at your own risk.
See my other answer above, you don't need to edit registry keys, the feature to unbind keys is there.