What version of Windows are you using? What CPU and PSU do you have installed? Make and Model of MoBo? etc.
Did you use DDU to uninstall the current AMD driver set? Did you download the Full AMD Driver set for your GPU?
Does your MoBo have the latest BIOS and AMD Chipset installed? Make sure your PSU (at least 500 watts) has enough power to run your system with the AMD GPU card under heavy load.
Be certain your latest Windows version is fully updated via Windows Update including "Optional" updates.
Also be sure to delete in the Root Directory C:\AMD folder BEFORE installing the current AMD drivers. Then AFTER installation of AMD driver set delete the C:\AMD folder again once the drivers are installed and working correctly.