Correct me if I'm wrong but it seems that disabling ULPS in the registry or via MSI Afterburner doesn't do anything in 17.11.1.
If ULPS is enabled on the M295X on an iMac 5k from 2014 then microstuttering is observed after about a minute or two of gameplay (because the card gets hot and Apple's thermal design of the iMac is not great for this card!).
It happens in pretty much every game (though COD WW2 strangely seems immune). Disabling ULPS has worked in every single driver version up until 17.10.3 to rectify this.
Just thought i'd put this out there.