As the Release Notes always say :
Radeon Software Crimson ReLive Edition xx.xx.x is a notebook reference graphics driver with limited support for system vendor specific features.
Mobility GPU's are heavily customized by the laptop manufacturer, and therefore, if you want to preserve all the features the laptop provides, you will need to stick with drivers provided by the manufacturer.
Does that mean I can never access AMD Radeon Settings? If I play a game, is my AMD Driver being used?