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First delete all your third party controllers..they conflict with Wattman (Afterburner,etc)
Sounds like a anti-virus program or similar running/checking in the background. Put a exception for your games in the anti-virus/anti-malware etc to 'not check/or monitor'.
Use 'msconfig' to stop unnecessary programs from running .
As there has been no update on this thread, I am locking the discussion.
If you are still experiencing the same issue, please start a new discussion and provide the essential information required by clicking this link > https://community.amd.com/thread/196209