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Civilization IV (4) uses DirectX 9.
Civilization VI (6) uses DirectX 11.
civ 6 fully support dx12, the dx11 exe works fine , the dx 12 exe loads to the main menu of the game but crashes when trying to get into a game or even just benchmark
Please try updating to Crimson 17.5.2 and navigate to Radeon Settings > Gaming > Global Settings and set the Power Limit to +50% and click apply.
If you have any software running in the background that uses an overlay, like MSI Afterburner, please close this prior to running the game as it can cause crashes.