Building new system with an MSI z270 Gaming M7 motherboard. 32g GSkill DDR4 3200
The system will not boot at all with the card and power supply connectors connected.
The system will boot with no display with the 8 power pin disconnected and the 6 pin still connected. No display from on board graphics or w9100 graphics.
It does boot and run windows 10 without the card installed.
It does not matter what slot it is in.