I like to use Instant Replay. If I'm in the middle of a game, and the heat of battle or whatever, I don't want to contort my hand into pressing two buttons at once. I'd like to be able to hit one button, even if it's globally captured, that I can use just for that function. Say, F6 or F7. There's really no technical reason this can't be done.
ReLive is a great feature in theory and was very easy to set up and use. I'm not using it, however, because these unnecessary keyboard restrictions make it too much of a pain. I hope AMD reconsiders.