I recently installed a new Sapphire RX-480 and I just used the ReLive recording software for the first time to record a match in Natural Selection 2.
There seems to be an issue in the top right of the screen with an orange box appearing as soon as I start recording. When I stop recording everything is normal and I can see everything on the screen. But as soon as I start the orange box re-appears and covers about a 3 inch by 3 inch or 5 by 5 centimeter square in the top right of the screen covering part of the game.
I think this might be related to the built in camera support and integrating multiple views into the recording. I don't know for sure but it would be nice to get rid of.
I've attached a screen shot of the problem and I also have a video here. NS2 Veil - YouTube
Radeon Software Version: 17.2.1
Windows 7 64 bit, i5 4670k, 12GB
LG 24GM77, DVI-D @ 144
ReLive recording at 60
I don't know why the screen shot looks that dark but it really isn't that dark. I took another one and it came out the same way.
Here it is on imgur: http://imgur.com/a/ZSxBQ