I recently installed a new Sapphire RX-480 and I just used the ReLive recording software for the first time to record a match in Natural Selection 2.
There seems to be an issue in the top right of the screen with an orange box appearing as soon as I start recording. When I stop recording everything is normal and I can see everything on the screen. But as soon as I start the orange box re-appears and covers about a 3 inch by 3 inch or 5 by 5 centimeter square in the top right of the screen covering part of the game.
I think this might be related to the built in camera support and integrating multiple views into the recording. I don't know for sure but it would be nice to get rid of.
I've attached a screen shot of the problem and I also have a video here. NS2 Veil - YouTube
Radeon Software Version: 17.2.1
Windows 7 64 bit, i5 4670k, 12GB
LG 24GM77, DVI-D @ 144
ReLive recording at 60
I don't know why the screen shot looks that dark but it really isn't that dark. I took another one and it came out the same way.
Here it is on imgur: http://imgur.com/a/ZSxBQ
I have the exact same problem. It is caused by the camera. Your webcam software displays an orange screen when it's turned off, but ReLive doesn't know this. Just disable the camera in ReLive settings.