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I'm using a Radeon Pro Duo, but you've not really provided much useful information that allows me to help. Read this and maybe supply a screenshot too.
AMD Graphics Card
- AMD Radeon Pro Duo 16GB (refrence card)
- Desktop Clone PC Build
- Windows 10 64bit Pro
- Driver version installed
- Radeon Software Crimson Edition 17.1.2
- Display Devices
- LG 34UC88-B 3840x1440 @60Hz DP with FreeSync enabled
- ASUS Rampage V Edition 10
- I7 5960x overclocked @ 4.5 Ghz (1.3V)
- Power Supply Unit Make, Model & Wattage
- Corsair AX1500i 1500 W
Corsair DOMINATOR Platinum Series 32GB (4 x 8GB) DDR4 2666 (PC4-21300) 2666MHz C15 memory kit (CMD32GX4M4A2666C15)
Describe your issue:
The Graphic card detects both Radeon GPUs and is usable in 2d Windows Desktop, however when playing 3D game or lunching Radeon Crimson application there are strange artifacts showing up in the Radeon window (looks like I can see some of my background through it *white dots in the image below)
Also the Games are unplayable with strange jiggled pixels unrecognizable shapes etc.
Rolling back the driver with clean installation did not resolved this issue. I swapped to my old Radeon R9 295x2 and its working fine without any problem on this same system,
Try using a different display port cable and a different dp connection on the Pro Duo, the cable bundled with the monitor could be of low quality.