I have this setup
AMD Drivers 16.Q4.1
I used a Samsung T220 connected by original display-port to DVI adapter 1680 x 1050 at 60 Hz - ALL OK
I use a Benq BL2420PT connected by original display-port to DVI adapter 1920 x 1080 at 60 Hz - ALL OK
If I use a display-port cable connected at 2560x1440 - Sometimes monitor flicks and shutdown!!!
I try other drivers - Radeon Pro Software Crimson ReLive Edition 16.12.1 and 15.301.2601 Solidworks Certified. - NOT SOLVED
Other display-port cable - NOT SOLVED
Use other display-port on W5100. - NOT SOLVED
Today I install a OLD Quadro 600 connected by original display-port 2560 x 1440 - I have not had any problem yet.