You may send report here I don't see another workaround than uninstall 16.12.1 and use 16.11.5
16.12.1 is unstable for many configurations and has lots of problems . Just wait for more stable and mature version of 16.12.x or 17.01.x(if only it will be more stable)
I have similar issues with 16.12.1. Far Cry 2 now crashes back to the desktop after less than a minute of gameplay. The problem did NOT exist with 16.11.5.
Have reported this to AMD via the link from redfury and will revert back to 16.11.5.
I also found that ASUS GPU Tweak II bacame very sluggish with 16.12.1.