Have you checked Event Viewer to see if that lists any errors?
It is the 16.12.1 driver. As soon as i installed it i was having issues - my second screen would lose connection and go into what looks like white noise. I also get constant crashes in every game. Complete freezing and having to hard reboot. I reverted back to 16.11.5 and everything is working perfect again. I suggest rolling back until they fix their drivers.