To add: 16.12.1 also re-introduced the mouse corruption bug for me.
Happens on a dual-monitor setup. Same sorta thing as before. Maybe some extra QA love is needed before drivers are pushed out.
To reply to your message I am also on a dual monitor setup.
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We are aware of the issue and it will be addressed in a future driver release.
Like others have said, workarund fix is turning Mouse Trails, set it to shortest, a tab bit annoying, but hey, neat little fix till AMD gets on it, posting because I just installed Asus RX 480 Strix 8G and sadly got hit with the corruption today when I opened Word 2016. had this issue way back on the Fury X, but was more display corruption due to downclocking inaccuracies.
Windows 10 Pro 64
fresh install of 17.2.1
Dual Monitor setup, Main is a 1080p 144hz monitor.
iGPU is powering my other monitor. (tiny D-SUB only 18", dont have Dsub to DVI)