Rise of the Tomb Raider is very demanding game. Your RX 460 is not enough even for Full HD. In any case, lower your texture quality first of all.4GB is not enough for ULTRA. And don't even try to enable anti-aliasing SSAA.
Maybe this is the problem with the use of RAM when I play the game rise of tomb rider process called "system and compressed memory" can even take 3GB RAM
and tested in this game
windows 10 Generation 2 (1511) 10586.164 someone had a similar problem with the process the last time he took me almost all the RAM in the game ...
process "system and compressed memory" increases only when I start the game ...pls help.
"system and compressed memory"-yeah, it is a plague of win10.
You need to upgrade your win 10 to 1607 version (anniversary update) first of all.
Check your windows updates or use "media creation tool" for manual update.
I found this tutorial from Google when searching for solutions to fix the same problems.
It was helpful and help me to fix my problems.