I'm using AMD Radeon R9 M200X Series on Windows 7 x64.
After an update at the end of October 2016, and after starting up Windows for some minutes, my computer doesn't respond with mouse click anymore, windows lose focus when I click, but nothing responds. I followed the trick in this link Cannot click on anything in Windows 7 - Super User, which is to try CTRL + ALT + DEL then press cancel to force display driver to refresh and it really works!
I rolled back to previous driver version, however I cannot start AMD Radeon Settings software anymore, it only shows a semi-transparent window (see attached screenshot).
As it's hard to find a place on web to file a complaint to the producer, so I leave a note here just in case any AMD employees can see and help fixing this driver bug.
Try the troubleshooting steps in the document below, using DDU to remove your current AMD drivers, then updating Windows fully and updating to the latest driver.