Issue: When switching from Windowed mode to Exclusive Full Screen (or Alt+Tabbing from exclusive full screen) the game will start to flicker (as shown in the included video). If Crossfire is disabled in the drivers then the issue doesn't happen. The flickering doesn't always happen, but its consistent enough to be replicated.
Once the flickering starts, the only way to fix it is to either, a) play the game in windowed mode and forfeit the power of the second card, or b) restart the game.
The issue happens with many different games (not limited to just Overwatch).
Operating System: Windows 10 Pro 64-bit (10.0, Build 14393)
Processor: Inte i7-4930K CPU @ 3.40GHz
Motherboard: Asus Rampage IV Black
Memory: 16GB RAM
Graphics Card: AMD R9 295x2
Display 1: BenQ XL2730Z connected via Display Port
Display 2: Asus VE278Q connected via DVI
PSU: Corasir AX1200i
Neither the CPU or GPU are currently overclocked.
Driver version: 16.10.1 (The issues has been happening for multiple driver versions and I use DDU whenever installing a new driver).
Edit: Updated system specs