Eyefinity and profiles is broken for me as well.
There are two types of profile: Game profiles and Eyefinity profiles.
You are talking about game profiles where you enable/disable eyefinity per game, right? The other kind of profile is eyefinity profile. When you choose "Advanced setup" in crimson for creating eyefinity then the old catalyst UI appears. After you have created an eyefinity profile there, you can give it a name. But why? There is no option to choose later on this certain profile again. At least I didn't find any option to do so. Who can help me?