Whenever I purchase a new graphics card I do a clean install of Windows. Saves hours and hours of troubleshooting.
If the problem still occur's after that return the card right away. Don't get caught up in the "we're aware of the problem" or " wait for an update" thing. Most reputable dealers will either give you your money back or a store credit if the card is returned in a few days. In some countries it's even the law I believe.
I have the excact same problem, but I've done it from a clean windows 10x64 install.
Trying to install the recommended driver (Crimson 16.6.2) leads to a system freeze and the inability to boot to desktop. I have to unpower the GPU, and use the onboard socket for reaching my desktop successfully. I've just reinstalled windows 10, so there are no previous drivers. Running windows update will crash the system too.
Attempting to install the driver in safe mode leads to the error message "Can't detect graphics card"
My specs: * AMD Rx 480 (sapphire) * Sabertooth z77 * Intel I5-3570k * Windows 10 64 bit
I also have the sapphire version of this card
Reinstall Windows doing a Clean Install.
Once it's done install the Chipset Drivers. Reboot
Install Audio Drivers. Reboot
Install Ethernet driver. Reboot
Install Windows Update. Reboot
Go Back to Windows Update and see if additional ones have shown up. Install and reboot.
Download and install the newest NetFramework and reboot.
Ok, now the graphics driver. Install the newest drivers for your card and OS.
If problem persists, return card.
I'll definitely try a clean install
Clean install worked like a charm