I am using Sapphire Nitro 380X on UEFI mode (the little switch on top of the card)
OS is Windows 7 64-bit
my mobo UEFI is also everything set to UEFI mode, except for VGA when booting (due to Windows 7 refusing to boot as "Class 3" UEFI)
Driver is 16.6.1
Tests using Shadow of Mordor work mostly fine, game even manages to stay above 60fps for 99% of the time with everything on Ultra except the textures (that are on "very high" instead)
As soon as I visit the plants on the in-game encyclopedia, to read what the "herbs" do, the game shuts down, claiming I lost my display adapter, and Windows display a pop-up near the clock saying the GPU drivers rebooted.