I used the same way as with 16.4.2, Display -> Additional Settings -> CCC -> Gaming -> Disable
This is needed for Fallout4 because of the flickering issue with blue or green textures.
With this version I do the same setting to disable Crossfire, but the second card will not turn off. I can see temperature and clockspeed in MSI Afterburner but 0% usage in the game. I get the same bugs as with Crossfire enabled.
Using DDU in SafeMode, I tried to downgrade to 16.4.2, but no change