AMD R9 Fury X
Windows 10 64Bit
Radeon settings Crimson 16.4.2
MSI Gaming 5 Z97 Mobo
i7 4790K 4.6GHz
16GB 2400MHz DDR3
Radeon settings Game Profiles not applying in Game
Everything Exept Forcing AA works in Global Profile
Nothing Exept Shader Cache works in the Individual Game profile. No AA, No AF, No FRTC, etc
I've found game profiles not to work for me in many cases, because the values are wrongly applied to global settings, which apparently overwrite game profiles currently.
You might try checking your global settings if they are stuck at some unexpected value.