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I think you mean 4/4/"2016" otherwise those drivers would be a year old. Anyway, I think I have the exact same problem. I only have a few games to try currently but most of them won't start (just get a black screen, with a flickering mouse sometimes). Most of my games are on steam however it also happens when I try to play Starcraft II. I've been able to work around the issue for most games by running them in Windowed or Borderless Window mode which seems to fix the issue. I thought maybe it was a crossfire issue because of this, however I am still unable to launch almost any of my games in fullscreen mode even after setting crossfire mode to disabled in the game's profile. Unfortunately it isn't always easy to get the games I want to play to start in windowed mode the first time I run them. I am currently trying to play Dust: An Elysian Tail, but I just get a black screen when I try and there doesn't seem to be an easy way to set the game to startup in window mode without been able to get into the game to change the settings first.
I am running Windows 10 64bit with latest drivers (16.4.1), I have 2x HD 7970 graphics cards in crossfire configuration. I also have two monitors hooked up. One through an active Displayport -> DVI adapter and the other using a DVI -> VGA adapter (the DVI port is broken on this monitor).