What version? I have 4.3.1.0698 and believe it's the newest. You might not want to uninstall if it's working.
Another option is to use Revo Uninstaller to see if it'll get rid of it.
Please try the following to troubleshoot your issue.
1. Run the Windows self check tool to check scan and automatically repair any corrupt files found in Windows. There is a guide on how to do it here. What you need to do is run an elevated command prompt (elevated means run it as administrator) and type SFC /SCANNOW. This will generate a statement indicating if errors were found the Operating system and if they were fixable. Don't panic if they are not able to be repaired, continue with the steps below. If the steps below don't resolve the issue, then it's time for a fresh Windows installation.
3. Update Windows. Install all available critical, recommended and optional updates. Often Netframework and Visual C are included in the recommended or optional updates Windows provides.
4. Use DDU to sweep the system of AMD drivers.
5. Attempt to install the latest Crimson 16.3 drivers once the above is completed.
I had same problem. I tried re downloaded and then reinstalled overdrive but chose repair during install process. Then when it asked me to restart i said no and i uninstalled overdrive completely. I wasn't looking to fix it i was wanting it off my computer.