I had the same issue with a r9-fury,except no drivers worked for it.. I sent it back for a refund... I'm not paying $500 to beta test for AMD..
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No problems here at all...R9 380 4GB, Win10x64, Crimson 16.3's....I have nothing against DDU, or anyone who chooses to use it, but I will say I don't use it because I found it to be destructive and to remove more files than should be removed, etc. The standard Crimson install/uninstall routines work perfectly--and they leave your profiles untouched at the same time. I've not experienced any problems with them that makes me think again about DDU. Half the driver-related problems I see on these boards are from people using a DDU version made for older drivers on their newer drivers, too. As well, stay far away from "registry cleaners" and "PC Mechanics" programs of all kind that mess up people's systems far more than "fix" them--those auto-repair programs can easily ruin a perfectly healthy system. (Advice to the wise...;))
The most common mistake I've seen with the Crimsons is that I've found it's better to uninstall the old drivers first (using the Crimson uninstall routines), and then install the new drivers. That seems to work better than installing one beta, non-WHQL driver on top of the next, imo.
Hope you get it sorted...
In the past ive used the Amd clean uninstaller but I switched to ddu after it failed to remove all the drivers. I will try to just use the Uninstall routine instead and then install 16.3. I also found that I needed to run some windows updates and those fixed some other minor driver issues I was having.