I have tried re installing Crimson, this did not help.
We are investigating reports that users are not able to disable CrossFire via using a game profile in Radeon Settings.
Dual GPU cards, such as the R9 295x2 have never had the option to physically disable CrossFire, this was always done via game profiles. The option you may be referring to was to enable the default CrossFire profile, AFR Friendly, for applications that did not have an existing CrossFire profile.
Please try adding the Spintfires executable to Radeon Settings and editing the profile to say CrossFire disabled. If this does not work, with try running the game in windowed or borderless windowed mode which will force CrossFire to disable.