You normally need to install certain drivers (or patches), with a new or an old O/S. These are typically supplied by the mobo maker as the drivers are required to allow the mobo devices to function with a specific O/S. The may even be AMD CPU specific drivers from some mobo or O/S makers. You might be able to find these drivers at the mobo makers or O/S makers website under "downloads" and/or in the Support area.
Old Operating-Systems like MS-DOS, DR-DOS or Windows 3.1(1) do not need special Drivers to work. They work with Standard-Drivers that are based on Standard-Hardware-Layer (i.e. 8086-compatible, VGA-Compatible, SVGA-Compatible, ATA/IDE-Compatible, etc.
So this cannot be the reason. The only reason might be, that the Hardware is no longer compatible to these Standards - and that is my question to the Tech-Guys @AMD
FYI - These are the AMD User Forums. They are NOT officially supported by AMD Technical support. If you want an official reply from AMD Tech then you need to submit a Support Ticket.
There is at least one iteration of Windows that does require an AMD CPU driver to run Windows. It's been well over two decades since I've used those old Windows versions so I can't tell you which iteration of Windows it was. There are also numerous Windows "patches" for AMD CPUs that are required for the AMD CPUs to perform properly even with the latest desktop FX CPUs as shown in the link below.
That being said my personal experience with Windows is that if you install and remove it more than once on a specific hard drive, there can be remnants of a previous O/S installation that causes Windows to get confused and hang or crash. If you have the Windows CD you can try to "repair" the Windows installation. I've only seen Windows "repair" resolve a problem, one time in 20 years. If "repair" does not work you can try a complete new Windows install typically after running "repair" and rebooting your PC. A new install of Windows has about a 50:50 chance of fixing the conflicting files issues on a Windows install, IME. Any updates that have been installed since the original O/S installation will be newer files and the "repair" mode will ask you if you want to replace various Windows files. IME, going with all of the original Windows files on the CD, NOT the updated files, is the only "repair" that ever worked for me.
Unfortunately there is no good known means to fix corrupted Windows installations short of reformatting the drive and a new install. Even hard drives that have only had one installation of the Windows can end up with conflicting files or corrupted files from Windows updates. Your mileage may vary when it comes to fixing a Windows installation. (YMMV).
BTW, there are no known issues per se with AMD processors running Windows regardless of the version. Using the appropriate driver when needed and the Windows "patches" will deliver the best performance from AMD processors. Your Windows issue is not an AMD CPU issue.
The biggest problem is there are no drivers for the motherboard chipsets for old operating system. Now days you are lucky to find drivers for even Windows XP.
Your best bet for old operating systems on current hardware is to use Virtual Machine software such as VMware or VirtualBox. Virtual Machine programs can emulate the required hardware for operating systems from DOS to Windows 10.
Using VMware Workstation Player I have installed:
Windows for Workgroups 3.11
Windows 10 Pro 32-bit
Windows 10 Pro 64-bit
BTW, my computer has the following hardware:
CPU: AMD FX-8350
MBD: Gigabyte GA-990FXA-UD3
RAM: 8GB GSkill (DDR3-1600)