after the latest update Endless Space doesn't work with Crossfire anymore. The game was running fine with Crossfire before, now it doesn't. I have to manually disable Crossfire to get to work again in fullscreen. Disabling Crossfire just for Endless Space in the Crimson driver, doesn't seem to actually work. Running the game in windowed mode works though.
We're investigating an issue in 16.1 that causes profile settings to be lost or not apply correctly. I would recommend rolling back to an older version of Crimson or Catalyst until we release our next driver.