It's odd, I had almost this exact same problem a few months ago with 15.7.1 but I think at that time it was because I had installed drivers on top of one another instead of doing it the right way.
So I uninstalled 15.7.1, loaded up safe mode and ran DDU to clean everything off. Then I installed the crimson drivers. They installed just fine and ran just fine. But the application profiles either aren't working OR there is something wrong with crossfire. I could NOT get Crossfire to disable using the application profiles. Every time CS:GO loaded up it was trying to run using both GPU's(which is bad for CS:GO). I finally just disabled CF altogether through the old CCC interface that pops up(additional settings) and that worked HOWEVER in game CS:GO was stuttering/freezing every 5 seconds or so. Very weird, very unplayable.
So I did a total uninstall/wipe/reinstall again just to be safe, same issue. Couldn't figure it out.
Ultimately had to roll back to 15.7.1. Anybody else have a similar experience and know how to beat it? It's a little frustrating because a lot of new games have come out recently and it would be nice to have the latest optimized drivers. But of course having CF working correctly is kind of a necessity.