Delete your old CCC profile and make a new one for games in which you have that problem. I was having the same trouble--with profiles somehow getting scrambled. That's what fixed it for me.
Thanks for the suggestion, waltc! Unfortunately it does not solve my issue.
Fallout 4 is running poorly too...the textures take forever to load the higher detail versions and I get very weird lag...like framerate dropping 20FPS...but the framerate reads constant. It's kinda like when you used to have lag from loading HDDs...but I have a PCIE SSD and the game ran flawless yesterday.
I'm just going to revert back to the old driver unless anyone has a solution.