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If you do a quick research on the internet or on this forum, you'll find out that many users with different gpu brands and gpu architectures are experiencing similar framerate and performance issues in Fallout 4.
The game will be patched on the forthcoming week, so let's all hope that many performance issues and bugs will be ironed out.
Try disabling vsync and using a frame limiter (CCC or Rivatuner statistics/ afterburner) to cap your fps to your monitor's refresh rate or to your minimum/ average fps in-game.
Thanks for the reply. I'll try that and if not I'll wait for the patch
Try to disable windows defender in windows 10,
Right click on"my computer>select "first page of control panel>change to large icon from the upper right of control panel page>choose "windows defender">settings>switch off windows defender.
maybe helpful to improve system performance,because windows defender alwatys access your system.
Please notice,everytime you have reboot or re log-in your system,windows will enable automatically.
Hope this helpful and sorry for my poor English.