Are you definiely using the correct game executable? It sounds as if you may not be using the right one. Double check and set CrossFire to disabled in the game profile.
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*I don't why i can't edit the previous post.
I make a mistake in my previous post : The problem isn't resolved with Crimson driver
The problem is identical when i use only the R9 295x. I removed the r9 290x from the pc.
According to my research on the internet, these are the games using DX9/DX10 that pose problems. The profiles don't work